Transforming Growth Factor β Receptors in Verrucous and Squamous Cell Carcinoma
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چکیده
منابع مشابه
Aberrant Methylation Inactivates Transforming Growth Factor β Receptor I in Head and Neck Squamous Cell Carcinoma
Background. Alterations in TGF-beta signaling are common in head and neck cancer (HNSCC). Mutations in TGF-beta type II receptor (TbetaR-II) occur frequently in HNSCC while TGF-beta type I receptor (TbetaR-I) mutations are rare, suggesting that other molecular alterations in the TGF-beta pathway are likely. To identify abnormalities in TbetaR-I expression we analyzed 50 HNSCCs and correlated th...
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Transforming growth factor (TGF)-b is a potent regulator of growth and differentiation in normal squamous epithelium. TGF-b exerts its antiproliferative effect via the TGF-b type II receptor (TbR-II). A decrease in TbR-II expression is believed to be responsible, in part, for the resistance of squamous cell carcinoma (SqCC) to the antiproliferative effects of TGF-b. In the present study, we use...
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ژورنال
عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery
سال: 1999
ISSN: 0886-4470
DOI: 10.1001/archotol.125.8.849